ea0020p357 | Diabetes and Cardiovascular | ECE2009
Boulton David
, Tang Angela
, Patel Chirag
, Li Li
, Xu Xiaohui
, Frevert Ernst
, Kornhauser David
Background/aims: Saxagliptin is a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme. Saxagliptin is cleared by both metabolism and renal excretion. The aims of this study were to determine the effect of renal impairment (RI) and haemodialysis (HD) on the pharmacokinetics of saxagliptin.Methods: This open-label, parallel-group study was conducted in subjects with normal renal func...